Is the recipient's mailbox full?

No, a full mailbox usually returns a 552 4.2.2 error. This error is strictly about the *rate* of incoming mail.

Can I force the delivery?

No, you must wait for the recipient's rate limit window to reset.

The intended recipient is receiving emails at a rate that exceeds their provider's limits, preventing your message from being delivered right now.

The recipient's inbox is being flooded with emails (e.g., an email bomb attack).
The recipient is a popular alias or distribution list receiving too much mail at once.
Your infrastructure is sending too many concurrent messages to the same user.

Let your mail server automatically retry delivery later.
If you are sending multiple emails to the same user, space them out over time.
If the recipient is an internal user, check if their account is under attack or misconfigured.

Gmail. Indicates 'The user you are trying to contact is receiving email too quickly.'

450 4.2.1 The user you are trying to contact is receiving email too quickly. Please resend your message at a later time.

Is the recipient's mailbox full?: No, a full mailbox usually returns a 552 4.2.2 error. This error is strictly about the *rate* of incoming mail.
Can I force the delivery?: No, you must wait for the recipient's rate limit window to reset.